At Picterus, we are committed to improving neonatal jaundice screening through rigorous clinical research, supported by peer–reviewed evidence and realworld validation across diverse care pathways, including both clinical and home settings.
The current commercialised version of Picterus Jaundice Pro represents the most mature iteration of the technology and is supported by the most recent clinical evidence. This version is evaluated in the latest clinical studies (not yet peer reviewed), while additional ongoing and planned research explores future development approaches. A dedicated white paper summarises the performance of the current software generation based on the latest available data.
In-depth insight into Picterus technology
Want to learn more about the science and validation behind Picterus Jaundice Pro? Download our latest white paper to explore the clinical background, methodology, and global relevance of our screening solution.
Picterus Jaundice Pro has undergone multiple software generations since its initial clinical validation. Each generation represents a distinct version of the algorithm and user interface, reflecting ongoing development and improvements informed by clinical research and realworld use.
The earliest version of Picterus Jaundice Pro, evaluated in initial clinical studies with data collection between 2017 – 2019, and corresponding publication in the year after: Aune, Anders et al. “Bilirubin estimates from smartphone images of newborn infants’ skin correlated highly to serum bilirubin levels.” Acta paediatrica (Oslo, Norway : 1992) vol. 109,12 (2020): 2532-2538. doi:10.1111/apa.15287
This version relied on predefined analytical models informed by simulated skin characteristics and reference bilirubin values. The first generation of the app supported foundational feasibility and validation studies and established the clinical potential of smartphone based bilirubin screening. Details are described in the publication: Aune, Anders et al. “Iterative Development, Validation, and Certification of a Smartphone System to Assess Neonatal Jaundice: Development and Usability Study.” JMIR pediatrics and parenting vol. 6 e40463. 28 Feb. 2023, doi:10.2196/40463
Subsequent generations of the software introduced refinements to image analysis, calibration, and user experience, informed by additional clinical data, expanded use contexts, and feedback from healthcare professionals. This also included an updated version of the Picterus Calibration Card, with added colour swatches to open for a wider variety in colour interpretation.
Over time, the software evolved toward more data driven approaches, including the use of machine learning methods, enabling performance to be refined based on accumulated clinical experience. As earlier clinical datasets informed the development of newer software generations, they are not reused as independent validation cohorts. More recent clinical studies therefore focus on evaluating the performance of the current version of the app.
When reviewing the clinical evidence, it is therefore important to consider the software version used in each study, as well as the intended use context at the time of evaluation.
Validation of a Mobile Health Device for Neonatal Jaundice Screening: A Cross-Sectional Study in a Resource-Limited Setting in Mexico.
Smartphone-based screening of neonatal jaundice in three populations in low and middle-income countries: a cross-sectional study.
Neonatal jaundice detection in low-resource Mexican settings: possibilities and barriers for innovation with mobile health.
Iterative Development, Validation, and Certification of a Smartphone System to Assess Neonatal Jaundice: Development and Usability Study.
Healthcare workers’ perceptions about the use of mobile health technologies in public health facilities in Lagos, Nigeria.
Bilirubin estimates from smartphone images of newborn infants’ skin correlated highly to serum bilirubin levels.
At Picterus, continuous improvement is guided by ongoing clinical research and realworld data. Our research pipeline focuses on the systematic evaluation and refinement of our technology across key areas:
This Course will equip you with the essential knowledge and practical skills to confidently assess and manage neonatal jaundice, using tools like Picterus® Jaundice Pro for accurate screening. You’ll also explore clinical guidelines and best practices to ensure that your decisions align with clinical recommendations.
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